How Many Times a Night Is Normal to Urinate? What Counts as Nocturia and What to Do About It
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Getting up once a night to urinate is common and usually not treated as a problem. Two or more times a night is the point where researchers and urologists consider it clinically relevant nocturia, because that is where sleep, daytime energy and fall risk start to suffer.1 How common it is depends heavily on age: clinically relevant nocturia is reported in 2 to 18 percent of adults aged 20 to 40, but in 28 to 62 percent of adults aged 70 to 80.1
The part most men get wrong: an enlarged prostate is only one cause, and often not the main one. The kidneys making too much urine overnight, sleep apnea, heart failure, diabetes, late-day diuretic pills and evening alcohol all wake men up just as reliably. A three-day bladder diary, which you can start tonight, is the single most useful step toward finding out which one is yours.
Key takeaways
- By the formal definition, waking one or more times to urinate is nocturia. The threshold doctors act on is two or more voids per night.1
- Prevalence climbs steeply with age: over half of people aged 80 have nocturia, and around half of men in their seventies wake at least twice a night.2,8
- In men, the main drivers are BPH, nocturnal polyuria (too much urine made overnight), overactive bladder, obstructive sleep apnea, heart failure, diabetes, diuretic timing, and evening fluids, alcohol or caffeine.4,5
- A 3-day bladder diary that records time and volume of every void is the tool clinicians use to tell these causes apart.1,2
- Nocturia is the one part of the prostate symptom score least likely to improve with any BPH medication, per the American Urological Association guideline.7 That applies even more to supplements.
- Blood in the urine, inability to pass urine, fever with urinary symptoms, or unexplained bone pain or weight loss mean a doctor first, not a bottle.3,5
What counts as nocturia, and what counts as normal
Nocturia is the medical word for waking up from sleep to urinate. The International Continence Society definition is broad: the need to void one or more times during the sleeping period of the night, with each trip preceded and followed by sleep.1 By that definition, a huge share of adults have nocturia and most of them are fine.
That is why clinical reviews draw a second line. Nocturia becomes clinically relevant at two or more voids per night, the point at which most people report being bothered and the effects on sleep start to add up.1 Mayo Clinic uses essentially the same working definition when it describes nocturia as waking up more than once each night to pass urine.5
The healthy pattern works like this: at night, the body normally produces less urine than during the day, which is what lets most people sleep six to eight hours without getting up.4 When you are waking twice or more, either that overnight slowdown has stopped working, the bladder cannot hold what is being made, or a sleep problem is waking you and you notice a bladder that would otherwise have waited.
How common nighttime urination is by age
The honest answer to "is this normal for my age" is that it is common at every age past 50 and it gets more common every decade. A 2017 clinical review in the International Journal of Clinical Practice put clinically relevant nocturia (two or more voids) at 2 to 18 percent of adults aged 20 to 40, rising to 28 to 62 percent of adults aged 70 to 80.1 A 2024 review in the Tzu Chi Medical Journal reports prevalence above 50 percent by age 80, with much higher rates in everyone over 60.2
The Sleep Foundation cites figures in the same range: roughly 40 percent of adults aged 18 to 79 report nocturia in some form, up to 80 percent of older adults do, and around half of men in their seventies wake at least twice a night, with bothersome nocturia more likely to start after 50.8
Two things follow from those numbers. First, if you are 62 and up once a night, you are in the majority and you probably do not need to worry. Second, "common" is not the same as "harmless." The AUA describes nocturia as the most prevalent and bothersome of the lower urinary tract symptoms and notes it is associated with increased overall mortality.7 The 2024 review adds that it is the most common cause of disturbed sleep in older people and raises the risk of falls.2 That is not a reason to panic. It is a reason to take two or more trips a night seriously enough to get it looked at.
The main causes of nocturia in men
Almost every article on this topic jumps straight to the prostate. The research does not. Clinical reviews sort nocturia into three buckets: the bladder cannot hold enough (reduced capacity), you are taking in too much fluid, or the body is making too much urine overnight (increased diuresis). Together, those three explain up to 88 percent of cases, and the prostate lives in only the first bucket.1
Benign prostatic hyperplasia (BPH)
An enlarged prostate squeezes the urethra and irritates the bladder outlet, which produces a weak or interrupted stream, trouble starting, dribbling, urgency, frequency, and nocturia.3 It is the most common prostate problem in men over 50: the NIDDK estimates BPH affects 5 to 6 percent of men aged 40 to 64 and 29 to 33 percent of men aged 65 and older.3 The clue that BPH is involved is that the nighttime trips come with daytime symptoms too. Nocturia alone, with a strong stream and a bladder that empties fine, points elsewhere. Our prostate health hub covers the rest of the BPH picture.
Nocturnal polyuria
This is the one nobody's uncle has heard of, and it may be the most common. Nocturnal polyuria means the kidneys make an abnormally large share of the day's urine while you sleep: more than 33 percent of the 24-hour total in older adults, or more than 20 percent in younger adults.1 The bladder is normal. The prostate may be normal. There is simply too much urine arriving overnight, so you get up, often passing a full, normal-sized void each time. This is the cause the FDA-approved nocturia drug desmopressin is designed for, and it is not something a prostate pill or a prostate supplement can touch.9
Overactive bladder
Here the bladder muscle contracts before it is full, producing sudden urgency, frequent small voids day and night, and sometimes leakage. Mayo Clinic lists overactive bladder among the urinary tract conditions that lead to frequent urination.5 In a diary, this shows up as many small-volume voids around the clock rather than a few large ones at night.
Obstructive sleep apnea
Sleep apnea is the cause most likely to be missed, because men go to a urologist for it instead of a sleep clinic. The Sleep Foundation reports that nocturia occurs in up to 50 percent of people with obstructive sleep apnea, and that the breathing interruptions affect the hormones that control urine production, on top of the fact that someone who keeps surfacing from sleep is more likely to notice a bladder.8 MedlinePlus notes that nocturia may go away once the sleep problem is under control.4 The AUA guideline itself flags the role of sleep apnea in nocturia as "an area of great importance."7 Loud snoring, gasping, morning headaches and waking unrefreshed are the tells.
Heart failure, diabetes, kidney disease and leg swelling
MedlinePlus lists heart failure, diabetes, chronic kidney disease, high blood calcium and swelling of the legs among the conditions that lead to nighttime urination.4 The mechanism for several of these is fluid: during the day it pools in the legs, and when you lie flat it returns to the bloodstream and the kidneys turn it into urine. Uncontrolled blood sugar pulls water into the urine directly. If your ankles are puffy by evening, or you are also unusually thirsty, these belong on the list before the prostate does.
Diuretics and other medicines
Water pills (diuretics) taken in the evening do exactly what they are designed to do, at exactly the wrong time.4 MedlinePlus states plainly that if excessive nighttime urination is due to diuretic medicines, you may be told to take them earlier in the day.4 Mayo Clinic adds that opioids, cold and allergy medicines and older tricyclic antidepressants can produce symptoms that look like BPH.6 Bring your full medication list to any appointment about this.
Evening fluids, alcohol and caffeine
The simplest cause, and worth ruling out first. Drinking too much fluid during the evening, and caffeine or alcohol with or after dinner, are named by MedlinePlus as common causes of urinating more at night.4 The NIDDK gives the same advice for men with BPH: drink fewer liquids before bed and avoid or limit alcohol and caffeine.3
How to tell the causes apart: the 3-day bladder diary
This is the tool that separates guessing from knowing, and you do not need a prescription for it. Clinical reviews call the frequency volume chart pivotal to assessing nocturia, and the recommended minimum is three days.1,2 MedlinePlus tells patients to keep a diary of how much they drink, how often they urinate and how much, and to expect the clinic to ask for a voiding diary.4
How to do it
- Get a measuring container. A cheap plastic measuring jug or a urinal bottle with milliliter marks kept in the bathroom. Estimating does not work; the volumes are the whole point.
- Record every void for 3 full days and nights. Time and volume, every single time, including the first void of the morning.
- Record every drink. Time, rough amount and what it was. Mark coffee, tea, soda and alcohol specifically.
- Mark bedtime and wake time. Voids after you fell asleep and before you got up for the day count as nighttime voids. The first morning void counts toward the night's total volume, because that urine was made overnight.
- Note urgency and leaks. A quick mark next to any void where you had to rush, or did not make it.
- Note your medicines. Especially the time you take any diuretic.
What the diary tells a clinician
Two numbers fall out of the sheet. The share of your 24-hour urine that is made at night (the nocturnal polyuria index) tells whether the problem is overproduction. The size of your typical nighttime void tells whether the problem is a bladder that holds too little. A man producing 40 percent of his urine overnight in large voids has nocturnal polyuria. A man producing a normal overnight share in many small voids has a capacity problem, which is where BPH and overactive bladder live. A man whose diary looks normal but who still wakes constantly probably has a sleep problem, not a urinary one.1
| Cause | Clue in your diary | Who treats it |
|---|---|---|
| Enlarged prostate (BPH) | Frequent small voids day and night, weak or stop-start stream, feeling of not emptying | Primary care first, urologist if medicine does not help |
| Nocturnal polyuria | Large, normal-sized voids at night; more than a third of total daily urine made overnight | Primary care or urologist; sometimes cardiology or nephrology depending on the driver |
| Overactive bladder | Sudden urgency, many small voids around the clock, occasional leaks | Primary care or urologist |
| Obstructive sleep apnea | Voids scattered through the night; snoring, gasping, morning headaches, unrefreshing sleep | Sleep medicine (a sleep study is the test) |
| Heart failure or leg swelling | Swollen ankles by evening; large nighttime volumes; shortness of breath lying flat | Primary care, then cardiology |
| Diabetes or high blood sugar | High volumes day and night plus thirst; large drinks recorded to match | Primary care or endocrinology |
| Diuretic timing | Nighttime voids cluster in the hours after an evening water pill | Whoever prescribes it; often fixed by moving the dose earlier |
| Evening fluids, alcohol, caffeine | Big evening intake recorded; nighttime volumes drop on nights you cut back | You, starting tonight |
What a doctor will check
The AUA guideline is specific about the first visit for bothersome urinary symptoms. Statement 1 says clinicians should obtain a medical history, conduct a physical examination, use the International Prostate Symptom Score (IPSS) questionnaire, and perform a urinalysis.7 Here is what each piece is for.
The IPSS questionnaire
Seven questions, each scored 0 to 5, about incomplete emptying, frequency, stopping and starting, urgency, weak stream, straining, and nocturia, plus a quality of life question. The guideline describes it as a validated self-administered tool that shows the clinician how much symptom burden you are carrying.7 You can fill it out in the waiting room. The nocturia question is number seven.
Urinalysis
A urine dipstick cannot diagnose BPH, but the guideline explains that it helps rule out other causes by detecting bacteria, blood, white cells, glucose or protein.7 Glucose in the urine points to diabetes. Blood needs its own workup. Infection changes the whole plan.
Digital rectal exam and PSA
The NIDDK lists the digital rectal exam (DRE), in which the clinician feels the prostate through the rectal wall, and the prostate-specific antigen blood test among the standard evaluations for BPH.3 Both estimate whether the prostate is enlarged, and in the AUA guideline a PSA above 1.5 ng/mL or palpable enlargement on DRE is one of the criteria that decides whether a 5-alpha reductase inhibitor is appropriate.7 PSA also screens for prostate cancer, which is part of why "just try a supplement" is a bad substitute for this visit.
Post-void residual
A quick bladder ultrasound after you urinate, measuring how much is left behind. The AUA lists it among the optional studies at the first visit and says it should be performed before any procedural treatment.7 A large residual means the bladder is not emptying, which changes both the diagnosis and the urgency.
Blood tests and the diary
MedlinePlus lists blood glucose, kidney function (blood urea nitrogen and creatinine), electrolytes, urine culture and urine concentration among the tests that may be ordered for nighttime urination.4 And your three-day diary will be read carefully, because it is the only thing on this list that measures the night itself.
First-line changes with real evidence
These are the steps clinical reviews and government sources actually recommend, and several of them cost nothing. They are aimed mostly at nocturnal polyuria and fluid-driven nocturia, which is why they work for some men and do nothing for others.
- Move your fluids earlier. The 2017 review recommends minimizing fluid intake at least two hours before bed.1 The NIDDK says the same for BPH: drink fewer liquids, particularly before bed.3 Do not restrict fluids overall; that causes its own problems. Shift them.
- Cut evening alcohol and caffeine. Both are named causes, and both are among the easiest things to test with a diary.3,4
- Elevate your legs before bed. If fluid pools in your legs during the day, raising them above heart level for a few hours in the evening lets the kidneys process it before you lie down, rather than after.1,8
- Ask about diuretic timing. The 2017 review suggests taking diuretics mid-afternoon, timed to the drug's half-life, so the peak effect passes before bedtime.1 Never change the dose or timing of a prescription without asking whoever prescribed it.
- Get sleep apnea treated. The 2017 review states that nocturia often improves in patients with obstructive sleep apnea who use CPAP.1 For a man who snores, this may do more for his nights than anything a urologist prescribes.
- Treat the medical driver. Better blood sugar control, better heart failure management and treating a urinary infection each remove a cause rather than masking it.4
The uncomfortable fact about nocturia and prostate drugs. In the AUA's own evidence review, four trials of alpha blockers reported little to no difference from placebo in the frequency of nocturia (a mean difference of 0.13 voids per night), and the guideline states that nocturia is "the one component of the IPSS least likely to improve with any medical treatment."7 That is worth knowing before you spend money on anything, prescription or otherwise, on the promise of uninterrupted sleep.
Medical treatments
Alpha blockers
The AUA recommends offering alfuzosin, doxazosin, silodosin, tamsulosin or terazosin as a treatment option for bothersome, moderate to severe BPH symptoms (Moderate Recommendation, Grade A evidence).7 The NIDDK describes them as relaxing the muscles in the bladder neck, which improves flow.3 They work within days to weeks. They help overall symptoms more than they help nocturia specifically, for the reason in the box above.
5-alpha reductase inhibitors
Finasteride and dutasteride shrink the prostate over months. The AUA recommends them for symptom relief in men with a demonstrably enlarged prostate (volume above 30 grams on imaging, PSA above 1.5 ng/mL, or palpable enlargement on DRE), and gives a Strong Recommendation for using them, alone or with an alpha blocker, to prevent progression and reduce the risk of urinary retention and future surgery.7 The guideline also requires that patients be told about sexual side effects before starting.7 Note that 5-ARIs lower PSA readings, which your doctor accounts for when interpreting future results. Combination therapy, per the NIDDK, may work better than either medicine alone.3
Desmopressin, and its sodium warning
For nocturia caused by nocturnal polyuria specifically, the FDA approved a low-dose desmopressin nasal spray (Noctiva) for adults who wake at least two times per night to void.9 It works by telling the kidneys to make less urine overnight. Nocturnal polyuria in the approval trials was defined as nighttime urine production exceeding one third of the 24-hour total, and the label instructs prescribers to confirm the diagnosis with a 24-hour urine collection.9 In other words, the diary is not optional; it is how a doctor decides whether this drug applies to you at all.
The label carries a boxed warning for hyponatremia, dangerously low blood sodium. It is contraindicated in people at increased risk, including those with excessive fluid intake, illnesses that upset fluid or electrolyte balance, and anyone using loop diuretics or systemic or inhaled glucocorticoids. Sodium must be normal before starting, measured within seven days and again at about one month, and checked more often in patients 65 and older.9 MedlinePlus describes the hyponatremia as "serious and possibly life-threatening" and lists headache, nausea, vomiting, confusion, seizures and loss of consciousness among the warning signs.10 The 2017 review puts the rate of hyponatremia at 5.0 to 7.6 percent of users, most often in people over 65.1 It is an effective drug for the right patient and a genuinely risky one for the wrong patient, which is exactly why it is prescription-only.
Bladder medicines and procedures
For men whose diary points to overactive bladder alongside BPH, the AUA allows anticholinergic agents or beta-3 agonists in combination with an alpha blocker.7 When medicines fail or complications develop, procedures ranging from minimally invasive office treatments to surgery are options, and the AUA says surgery is recommended when BPH has caused kidney impairment, refractory retention or recurrent infections.7 Those decisions belong to you and a urologist, not to a web page.
Where supplements honestly fit
This site exists partly to evaluate prostate supplements, so we owe you a straight answer here. For nocturia, the answer is: not first, and often not at all.
Saw palmetto
Saw palmetto is the most studied prostate supplement and the results are not encouraging. The National Center for Complementary and Integrative Health states it is "probably not helpful" for urinary symptoms from an enlarged prostate, citing two NIH-funded trials, one at the standard 320 mg dose and one at up to three times that, in which it did not improve symptoms.11 A 2024 Cochrane update pooling 27 studies and 4,656 men concluded that saw palmetto alone provides little to no benefit, with high certainty evidence.12 The one useful thing NCCIH adds is that it does not appear to affect PSA readings.11 If you want to understand what those trials actually used, and why most bottles do not match it, our saw palmetto dosage guide goes through the numbers.
Beta-sitosterol
Beta-sitosterol is the plant sterol that appears in many prostate blends, sometimes as the headline ingredient. Its evidence base is separate from saw palmetto's and deserves its own scrutiny, which we give it in our beta-sitosterol for prostate review. The short version relevant here: nothing in that literature is specific to nocturia, and none of it addresses nocturnal polyuria, sleep apnea or medication timing.
Multi-ingredient drops and blends
Products like Prostadine combine saw palmetto with seaweed extracts, iodine and other ingredients in a proprietary blend without per-ingredient amounts and without a published trial on the finished formula. We go through what the label does and does not let you verify in our Prostadine review, and our guide on how to read a prostate supplement label shows how to check any bottle in a minute. The point for this article is simpler: if your diary shows nocturnal polyuria or your partner says you stop breathing at night, no blend on the market is aimed at your problem.
Why a supplement is the wrong first move when red flags exist
Some symptoms mean the question is no longer "what will help me sleep" but "what is wrong." Both Mayo Clinic and the NIDDK say to seek care right away for blood in the urine, inability to pass urine, and fever together with painful, frequent or urgent urination.3,5 Mayo adds pain in the side, lower belly or groin, and red or dark brown urine.5 Mayo also lists prostate and bladder cancer among the conditions that produce BPH-like symptoms.6 Unexplained weight loss or persistent bone pain alongside urinary symptoms are the kind of general warning signs that belong in a doctor's office, not a shopping cart. A supplement taken during the weeks it takes to "see if it works" is time a serious problem gets to grow. Get the urinalysis, DRE and PSA first. If everything is benign, you can decide about supplements afterward with the evidence above in hand.
A practical plan for tonight and this month
- Tonight: stop fluids two hours before bed, skip alcohol and caffeine after dinner, put your feet up for an hour in the evening. Start the diary.
- Days 1 to 3: record everything. Do not change anything else, so the numbers reflect your real pattern.
- This week: if you take a water pill in the evening, ask the prescriber whether it can move to the afternoon.
- Book the visit: two or more voids a night, any red flag symptom, or a diary that shows large overnight volumes all justify an appointment. Bring the diary and your medication list.
- Ask directly: "Could this be sleep apnea?" and "Does my diary show nocturnal polyuria?" Those two questions redirect more misdiagnosed nocturia than any prostate test.
Frequently asked questions
Is it normal to wake up once a night to pee?
Waking once is extremely common and usually not treated as a medical problem on its own. Under the International Continence Society definition, any waking to urinate is technically nocturia, but researchers and urologists treat two or more voids per night as the clinically relevant threshold, because that is the point where most people are bothered and sleep starts to suffer. If once a night is new for you, or it comes with other urinary symptoms, it is still worth mentioning at your next visit.
How many times a night is normal to urinate for a man over 50?
There is no single number that separates normal from abnormal, because normal shifts with age. Clinically relevant nocturia (two or more voids per night) is reported in 2 to 18 percent of adults aged 20 to 40, and in 28 to 62 percent of adults aged 70 to 80. The Sleep Foundation reports that around half of men in their seventies wake at least twice a night. Common is not the same as harmless, though: nocturia is linked to poor sleep, falls, and higher mortality in older adults, which is why two or more nightly trips deserve an evaluation.
Is waking up to pee at night always a prostate problem?
No. An enlarged prostate is one of several causes, and it is easy to blame the prostate when the real driver is something else. Nighttime urination can also come from nocturnal polyuria (the kidneys making too much urine overnight), overactive bladder, obstructive sleep apnea, heart failure, diabetes, chronic kidney disease, swelling in the legs, evening alcohol or caffeine, and diuretic pills taken too late in the day. A 3-day bladder diary is the simplest way to start telling these apart.
What is nocturnal polyuria?
Nocturnal polyuria means the body produces an abnormally large share of its 24-hour urine during sleep. It is generally defined as more than 33 percent of total daily urine produced overnight in older adults, or more than 20 percent in younger adults. It is one of the most common reasons for nocturia and it is not a prostate problem, so prostate medicines and prostate supplements do not address it. A bladder diary that records the volume of each void is how it is identified.
How do I keep a bladder diary for nocturia?
For three full days (and nights), write down the time and the amount of every void, using a cheap measuring container in the bathroom, and the time and amount of everything you drink, including alcohol and caffeine. Note when you go to bed and when you get up, and mark which voids happened after you fell asleep. Three days is the minimum experts recommend. Bring the sheet to your appointment: it lets the clinician calculate how much of your urine is made at night and how much your bladder is holding per void, which points toward the cause.
Does sleep apnea cause frequent urination at night?
It can. The Sleep Foundation reports that nocturia occurs in up to 50 percent of people with obstructive sleep apnea, and that the breathing interruptions affect the hormones that control urine production. A 2017 clinical review in the International Journal of Clinical Practice states that nocturia often improves in patients with obstructive sleep apnea who use CPAP. If you snore loudly, wake unrefreshed, or a partner has noticed pauses in your breathing, that is worth raising alongside the urinary symptoms.
Can saw palmetto stop me from waking up to urinate at night?
The best evidence says no. The National Center for Complementary and Integrative Health states saw palmetto is probably not helpful for urinary symptoms from an enlarged prostate, and a 2024 Cochrane update covering 27 studies and 4,656 men found little to no benefit. Nocturia is also the symptom least likely to improve with any BPH medication, according to the American Urological Association guideline, and most nighttime urination is not caused by the prostate in the first place. A supplement cannot fix nocturnal polyuria, sleep apnea, or a late diuretic dose.
Sources
- Oelke M, De Wachter S, Drake MJ, et al. A practical approach to the management of nocturia. International Journal of Clinical Practice. 2017;71(11):e13027. https://pmc.ncbi.nlm.nih.gov/articles/PMC5698733/
- Chang TL, Kuo HC. Nocturia, nocturnal polyuria, and nocturnal enuresis in adults: What we know and what we do not know. Tzu Chi Medical Journal. 2024;36(4):370-376. https://pmc.ncbi.nlm.nih.gov/articles/PMC11483088/
- National Institute of Diabetes and Digestive and Kidney Diseases (NIH). Prostate Enlargement (Benign Prostatic Hyperplasia). https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia
- MedlinePlus Medical Encyclopedia (NIH National Library of Medicine). Urinating more at night (Nocturia). https://medlineplus.gov/ency/article/003141.htm
- Mayo Clinic. Frequent urination: Causes and when to see a doctor. https://www.mayoclinic.org/symptoms/frequent-urination/basics/causes/sym-20050712
- Mayo Clinic. Benign prostatic hyperplasia (BPH): Symptoms and causes. https://www.mayoclinic.org/diseases-conditions/benign-prostatic-hyperplasia/symptoms-causes/syc-20370087
- American Urological Association. Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA Guideline (2021, amended 2023), unabridged. https://www.auanet.org/documents/Guidelines/PDF/2023%20Guidelines/BPH%20Unabridged%2002-20-24%20Final.pdf
- Sleep Foundation. Nocturia: Frequent Urination at Night. Medically reviewed by Abhinav Singh, MD. Updated October 24, 2025. https://www.sleepfoundation.org/physical-health/nocturia-or-frequent-unrination-night
- US Food and Drug Administration. NOCTIVA (desmopressin acetate) nasal spray: Prescribing Information, including Boxed Warning. 2017. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/201656lbl.pdf
- MedlinePlus (NIH National Library of Medicine). Desmopressin Nasal: Drug Information. https://medlineplus.gov/druginfo/meds/a682876.html
- National Center for Complementary and Integrative Health (NIH). Saw Palmetto: Usefulness and Safety. https://www.nccih.nih.gov/health/saw-palmetto
- Franco JVA, Trivisonno LF, Sgarbossa NJ, et al. Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement: an updated Cochrane review. World Journal of Men's Health. 2024;42(3):518-530. https://doi.org/10.5534/wjmh.230222